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Relationship between Hypomagnesemia and Glucose Homeostasis by Martina Montagnana, Giuseppe Lippi, Giovanni Targher, Gian Luca Salvagno, Gian Cesare Guidi

Background: Controversial data are available on the relationship between magnesium metabolism and glucose homeostasis.
Methods: We performed a retrospective analysis to retrieve results of serum magnesium and fasting plasma glucose (FPG) tests (7,659 outpatients >35 years old).
Results: Subjects with FPG value >7.0 mmol/L were more likely to had hypomagnesemia. The frequency of hypomagnesemia was also significantly higher among those with high FPG values >7.0 mmol/L. In multivariable linear regression analysis, magnesium was significantly associated with FPG only in patients with FPG >7.0 mmol/L.
Conclusions: Magnesium metabolism could be implicated in the glucose homeostasis, especially in patients with FPG values suggestive for diabetes.

DOI: Clin. Lab. 2008;54:169-172