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High and Low WWOX Gene Expression Levels in Acute Myeloid Leukemia - a Real Time RT-PCR Study by Walaa F. Elbossaty, Camelia A. A. Malak, Doaa Elghanam

Background: Although expression of WWOX was extensively studied in different tumors, WWOX gene expression in acute myeloid leukemia is not well-known or recognized.
Methods: Fifty control donors and fifty acute myeloid leukemia patients were enrolled in this research. The levels of WWOX gene in all participants were detected by RT-qPCR.
Results: Levels of WWOX gene in the AML group were significantly lower as compared to the control group (0.27205 ± 1.19812 vs. 10.501 ± 9.0338, respectively, p < 0.001**).
Conclusions: Decreased expression of WWOX gene ran parallel with acute myeloid leukemia regression.

DOI: 10.7754/Clin.Lab.2019.190119