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Discrepancy in Chloride Measurement with Decreasing Bicarbonate Concentrations by Shailesh Bihari, Steven Galluccio

Background: Accurate chloride measurement is important in critically ill patients.
Methods: Chloride concentration measured simultaneously between the central laboratory (indirect ion-selective electrode) and blood gas analysis (direct ion-selective electrode) were compared.
Results: We report a discrepancy with chloride measurement between the central laboratory and blood gas analysis at low bicarbonate levels.
Conclusions: Caution should be applied while interpreting the chloride concentration when indirect ion-selective electrode methodology is used, especially in the setting of low serum bicarbonate levels.

DOI: 10.7754/Clin.Lab.2019.190121