You have to be registered and logged in for purchasing articles.


A Case of Hemophagocytic Lymphohistiocytosis Secondary to Ralstonia Solanacearum Infection by Xiaowei Shi, Haohong Zhan, Yinzhu Zeng, Xiangzhong Zhang, Benquan Wu, Lingling Liu

Background: Hemophagocytic lymphohistiocytosis (HLH), as known as Hemophagocytic syndrome (HPS), is deemed to a severe clinical syndrome caused by excessive human being immune system activation. Bacteria of Ralstonia genus is a non-fermentative, gram-negative bacillus and also in the category of human opportunistic pathogenic bacteria. In this article, authors report a rare case of Hemophagocytic lymophohistiocytosis which probably was triggered by Ralstonia solanacearum (R. solanacearum) infection.
Methods: Hematologic investigation, biochemical examination, high throughput genetic test for infectious agents and bone marrow puncture.
Results: The patient achieved complete remission and no signs of relapse have as yet been found.
Conclusions: The bacteria of Ralstonia genus merely infect humans, and there were no reports about the infection of R. solanacearum in humans and secondary HLH. The prognosis of the patient in this case was very good. This result, we think shows that the relationship between HLH and R. solanacearum infection should be taken into the diagnosis process. Recognition of this will promote the correct diagnosis in clinical work.

DOI: 10.7754/Clin.Lab.2018.181118