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Serum Amyloid A is a Novel Inflammatory Biomarker in Polycystic Ovary Syndrome by Yifan Sun, Xianhua Chen, Bohui Ouyang, Gangxi Pan, Lin Sun, Sufeng Li, Kun Chen

Background: Serum amyloid A (SAA) is considered a biomarker of inflammation; however, the SAA levels in polycystic ovary syndrome (PCOS) are still uncertain.
Methods: In this study, SAA, glucose, insulin, C-reactive protein (CRP), follicle-stimulating hormone (FSH), luteinizing hormone (LH), and total testosterone concentrations were measured in 82 women with PCOS and 60 healthy controls.
Results: The median concentration of SAA was 5.000 mg/L (IQR: 2.825 - 5.400) in women with PCOS, which was significantly higher than that of controls (3.700 mg/L, IQR: 2.825 - 5.400, p = 0.025). SAA was only positively associated with the CRP (r = 0.303, p = 0.006). No significant association was observed between SAA and body mass index (BMI), total testosterone, or insulin resistance (IR).
Conclusions: SAA levels were increased in women with PCOS, and SAA may be a potential inflammatory biomarker for PCOS.

DOI: 10.7754/Clin.Lab.2018.181038