Abstract

Background: Cardiac troponin I (cTnI) is a well-established marker for detecting myocardial ischemic damage in neonates with hypoxic-ischemic encephalopathy. However, the predictive value of cTnI in assessing mortality in neonatal asphyxia remains obscure. This retrospective study aims to analyze the relationship between cTnI levels in blood serum with gestational age, birth weight, gender, delivery type, electrocardiography, echocardiography, Apgar scores, length of hospital stay, and mortality in asphyxiated neonates.
Methods: This study included 164 full-term neonates with evidence of asphyxia. Myocardial markers, electrocardiography, and echocardiography were assessed in the first 24 hours after birth in neonates with asphyxia. The length of hospital stay and short-term outcome were assessed.
Results: There were no statistically significant correlations found between cTnI concentrations and traditional markers of asphyxia, length of hospitalization or mode of delivery. However, high cTnI levels were significant predictors of mortality in neonates with birth asphyxia.
Conclusions: This study highlights the significance of monitoring cardiac injury in asphyxiated neonates. Serum cTnI levels measured at 24 hours after birth are likely to have significant predictive value for assessing mortality in neonates with birth asphyxia.

DOI: 10.7754/Clin.Lab.2016.151130