Abstract
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Yes-Associated Protein in Hepatocellular Carcinoma is Associated with Tumor Differentiation and Patient Age at Diagnosis, but not Markers of HBV Infection
by Cheng Wang, Zi-Man Zhu, Cheng-Li Liu, Xiao-Jun He, Xiao-Bin Feng, Lin Zhang, Jia-Hong Dong, Hong-Yi Zhang
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Background: It was necessary to assess the relationship between Yes-associated protein (YAP) and some clinical features of hepatocellular carcinoma (HCC), especially hepatitis B virus (HBV) correlation factors as they relate to tumorigenesis.
Methods: A tissue microarray including 84 HCC samples was retrospectively analyzed by immunohistochemistry.
Results: This study showed that YAP expression was associated with HCC differentiation and the patient age at diagnosis of HCC. The mean age at diagnosis of YAP(+) HCC patients was 46.19 ± 9.45 years old, which is younger than 51.40 ± 12.51 years old found for YAP(-) HCC patients (< 0.048). There was no significant correlation between YAP expression and HBV correlation factors (HBsAg, HBV DNA, and the duration of hepatitis B infection).
Conclusions: YAP(+) HCC patients had a younger mean age at diagnosis and more poor-differentiation characteristics of HCC. However, there were no independent HBV correlation factors.
DOI: 10.7754/Clin.Lab.2015.150704
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