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Background: As the incidence of allergic diseases increases, the detection of serum-specific immunoglobulin E (sIgE) becomes important for the diagnosis and management of allergic disease. This study aimed to investigate the diagnostic value of sIgE level in north east Chinese patients with allergic disease and provide more information for rational use of the sIgE results
Methods: A total of 1,215 patients with positive allergens by an sIgE assay were enrolled from the Second Affiliated Hospital of Harbin Medical University, China. Serum levels of sIgE to fourteen allergens were detected by AllergyScreen.
Results: Age of the subjects ranged from 0 to 86 years old, and 49.1% of them (597) were less than 18 years old. sIgE levels were grade 1 in 51.5% of them, grade 2 in 84.2%, grade 3 in 29.5%, and grade 4 and above in 13.2%. There was a significant difference in the positive rank of the house dust mite mix and mixing mold between the group of 4 to 12 year-old boys and the group of 0 to 3 year-olds and the group of over 30 year-olds. 280 patients were positive at grade 1; if grade 2 was taken as the critical, 23% patients would be negative.
Conclusions: The positive rank of sIgE was grade 1-3 in most cases and few patients were over grade 4. If grade 2 was taken as a positive judgment basis, 23% of patients would be mistakenly judged as negative. Serum sIgE levels may have value for the prevention and management for allergic disease.
DOI: 10.7754/Clin.Lab.2015.141220
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