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The Role of Remote Ischemic Preconditioning in Ischemia-Reperfusion Injury in Rabbits with Transplanted Lung by Tao Jiang, Yuanyuan Liu, Mei Ma, Liang Zong, Xiaheding Yiliyaer, Haiping Zhang, Hui Zhu

Background: To observe the influence of remote ischemic preconditioning (R-IPC) and remote ischemic perconditioning (R-IPER) on the lower limbs of rabbits with lung allograft ischemia-reperfusion injury (IRI).
Methods: Sixty rabbits were randomly divided into one of four groups: control (C), classic ischemic preconditioning (C-IPC), R-IPC, and R-IPER. The allogeneic lung transplantation model was established in rabbits, and the protective effects of R-IPC and R-IPER on transplanted lungs were determined and compared to classic ischemic preconditioning (C-IPC) IRI. Changes in blood oxygen were measured in each group before and after transplantation. After transplantation, levels of serum malondialdehyde (MDA), superoxide dismutase (SOD), and tumor necrosis factor-α (TNF-α), lung wet/dry weight ratio, as well as quantitative and organizational differences in the lungs were analyzed.
Results: After reperfusion, blood oxygen values in the R-IPC group and C-IPC groups were higher than in the C and R-IPER groups at 60 minutes and 120 minutes after transplantation (p < 0.05). Serum SOD content in the RIPC and C-IPC groups was higher than in the C and R-IPER groups (p < 0.05) after reperfusion. Serum MDA, TNF-α level, and lung wet/dry weight ratio and quantitative measurements of histological damage were lower in the R-IPC and the C-IPC groups than those in the C and R-IPER groups (p < 0.05). No statistically significant differences were observed between the L-IP and the C-IP groups or between the R-IPER and the C groups.
Conclusions: Classic preconditioning and remote preconditioning of rabbit lung allograft IRI had similar protective effects. The lower limb ischemia with the remote processing method used in this experiment did not produce a protective effect for lung allograft IRI.

DOI: 10.7754/Clin.Lab.2014.141002