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Is There a Relationship between Small, Dense LDL and Lipoprotein - Associated Phospholipase A2 Mass in Dialysis Patients? by Derya Sonmez, Yasemin Fidan, Oguzhan Ozcan, Alper Azak, Mehmet Senes, Murat Duranay, Dogan Yucel

Background: We aimed to measure small, dense LDL (sdLDL) and lipoprotein-associated phospholipase A2 (LpPLA2) concentrations and to evaluate their relationship with other risk factors of atherosclerotic heart disease in dialysis patients.
Methods: Study group consisted of 30 peritoneal dialysis and 20 hemodialysis patients with 20 healthy control subjects. sdLDL was measured by homogeneous LDL assay after precipitation of Apo B containing lipoproteins with heparin-magnesium. Lp-PLA2 mass was measured by immunoturbidimetric assay.
Results: sdLDL concentrations in the samples collected before hemodialysis and peritoneal dialysis treatment were significantly higher than the control group (p < 0.05). Lp-PLA2 concentrations of both pre-hemodialysis and peritoneal dialysis groups were higher than control group (p < 0.05). There was not a significant correlation between sdLDL and Lp-PLA2. sdLDL concentrations are significantly decreased after a hemodialysis session.
Conclusions: sdLDL and Lp-PLA2 concentrations are increased independently in the end stage renal failure patients who are receiving dialysis treatment.

DOI: 10.7754/Clin.Lab.2013.130910