You have to be registered and logged in for purchasing articles.
Abstract |
The Activity of 8-Iso-Prostaglandin F2α as an Oxidative Stress Marker In Vivo in Paediatric Patients with Type 1 Diabetes Mellitus and Associated Autoimmunities |
Background: Oxidative stress and inflammatory reactions are known to hold an important role in the etiopathogeny and persistence of acute or chronic clinical entities. Isoprostanes - a group of prostaglandin-like compounds, active products of arachidonic acid - have proved to be representative biomarkers of lipid peroxidation. The aim of this study was to determine the activity of serum 8-iso-prostaglandin F2α (8iPGF2α), as an in vivo oxidative stress marker, in paediatric patients with diabetes mellitus type 1(DM1) and in a control group. The main goals of this study were the following: establishing a possible correlation between the activity of 8iPGF2α and the presence of an autoimmune disease associated with DM1 and identifying a possible correlation between 8iPGF2α, the value of glycosylated hemoglobin (HbA1c) and the pancreatic autoimmune markers GAD65, IA2, IA in the group of patients with DM1 and other associated autoimmune diseases. |