Abstract
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Psoriasis is Associated with Increased Framingham Ten-Year Risk Score for Coronary Heart Disease in Tunisians
by Monia Allal-El Asmi, Amel Mebazaa, Wiem Zidi, Yosra Zayani, Moncef Feki, Mourad Mokni, Amel Ben Osman, Naziha Kaabachi
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Background: To assess the ten-year cardiovascular risk for coronary heart disease (CHD) in psoriatic patients and to test the impact of psoriasis severity and dura-tion on cardiovascular risk.
Methods: A case-control study included 202 adult psoriatic patients and 202 con-trols.
Results: Risk CHD was estimated using the Framingham risk score algorithm. Patients had a higher ten-year Framingham risk score (13.62 11.86 vs. 9.23 8.04; p = 0.002) than controls. In addition, a high risk score and a very high risk score (> 40%) were more frequent in psoriatic patients compared with controls (p = 0.043 and p < 0.001, respectively). According to the severity of psoriasis, the ten-year cardiovascular risk increases progressively and significantly (11.84 10.08; 15.59 „b 11.79 and 16.92 14.13 for mild, moderate and severe psoriasis, respectively).
Conclusions: Psoriatic patients have significantly greater risks of developing coro-nary heart disease than controls in relationship with psoriasis comorbidities such as hypertension, diabetes, dyslipidemia, inflammation and probably with psoriasis itself.
DOI: 10.7754/Clin.Lab.2013.121009
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