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Abstract |
IL-1 Alpha Regulates CXCL1, CXCL10 and ICAM1 in Network Form in Oral Keratinocytes |
Background: Keratinocytes are the major constituent of epithelial cells at skin and mucosal surfaces such as oral mucosa. In our previous study, it was indicated that oral keratinocytes play active roles in oral mucosal adaptive immune response and an IL-á sub-network was identified. In the past decades IL-1, a revolutionarily an-cient cytokine, has attracted our attention for its important roles in innate and adaptive immune responses. In this study we aim to show the IL-á subnetwork in oral keratinocytes and explore its relevance in oral lichen planus (OLP).
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