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Background: Our aim of this study was to evaluate the possible association between homocysteine levels and Buerger's disease in a case-control study.
Methods: 25 patients with Buerger's disease based on Shionoya’s clinical criteria, and 25 heavy smokers along with 25 healthy non-smokers (control) were recruited for this study. All groups were matched for age. Plasma ho-mocysteine levels were measured in each patient and then compared between the three groups.
Results: The mean plasma concentration of homocysteine was 16.88 mmol/L in the Buerger sufferers; as for the smoker (group 2) and control (group 3) groups, the level was as low as 13.89 and 13.56 mmol/L, respectively.
Conclusions: Patients with thromboangiitis obliterans, especially those with a progressive course, benefit from the hyperhomocysteinemia screening test.
DOI: 10.7754/Clin.Lab.2012.110627
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