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Measurement of thyroid stimulating hormone (TSH) concentration is the first line test for the assessment of thyroid
function. However, interference may lead to falsely elevated TSH concentrations, unnecessary investigations,
and eventually misdiagnosis. Our case report describes interference by heterophilic antibodies on an automated
TSH assay leading to false positive results. Such interference was however not observed with another automated
platform. The assay format, the antibodies used, and the volumes required for the analysis may influence the results
and the sensitivity to interferences. It is therefore important to detect and report these interferences to stimulate
the continuing improvement of immunoassays. Furthermore, the effective tracking of interferences with immunoassays
is dependent on multidisciplinary collaboration and requires continuing cross-talk between physicians
and laboratory staff.
DOI: 10.7754/Clin.Lab.2012.120201
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