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Abstract

ORIGINAL ARTICLESerum CEA and CA19-9 Levels are Associated with the Presence and Severity of Colorectal Neoplasia by Hengyong Zhai, Junxing Huang, Chuanchun Yang, Yiwei Fu, Bin Yang

Background: High concentrations of carcinoembryonic antigen (CEA) and carbohydrate antigen 19-9 (CA19-9) were found in the serum of patients with colon cancer. We performed the present work to investigate the association between elevated levels of serum biomarkers (CEA and CA19-9) and shortened survival in patients with colon cancer.
Methods: We examined patients who underwent colonoscopies between 2001 and 2014 and measured and analyzed the serum CEA and CA19-9 levels of 362 participants.
Results: Elevated CEA concentrations were found to be associated with advanced invasion, lymph node metastasis, and short survival. Elevated CA19-9 concentrations also were associated with lymph node metastasis and short survival.
Conclusions: Elevated serum CEA or CA19-9 levels were found to be associated with shortened survival.

DOI: 10.7754/Clin.Lab.2017.170914