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Abstract

Complementing the Patient: a Complement Component Deficiency in a Patient with Recurrent Infections and Glomerulonephritis by David Sinclair, Graeme Wilde, Samantha Bex, Sheila Peters

We present a case showing the investigation of a 7-year-old girl with empyema and glomerulonephritis whose "immunological" defect was a single complement component (C2) deficiency which prevented her from activating her classical complement pathway. A defect in complement function should be suspected in any patient with severe or recurring pyogenic infections. Investigations of "? immune deficiency" should always include tests to assess the patency of the patient's complement system.

DOI: Clin. Lab. 2005;51:505-507