Abstract

Background: Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening disease that is commonly caused by lymphoma. The authors describe laboratory features and the successful treatment of two patients with lymphomaassociated HLH.
Methods: Hematologic investigations, bone marrow aspirates and biopsies, and PET/CT scans were performed. Both patients received a transplantation of allogenic peripheral blood stem cells after chemotherapy.
Results: The patients achieved complete remission and have survived for three or more years after treatment with chemotherapy and an allogenic peripheral blood stem cell transplantation.
Conclusions: Allogeneic peripheral blood stem cell transplantation may be the most effective therapy for patients with lymphoma-associated hemophagocytic lymphohistiocytosis.

DOI: 10.7754/Clin.Lab.2013.131123